D-dimer product of?

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Multiple Choice

D-dimer product of?

Explanation:
D-dimer is produced when plasmin degrades cross-linked fibrin. After a clot forms, fibrin is stabilized by cross-links created by factor XIIIa. When fibrinolysis occurs, plasmin cleaves this cross-linked fibrin, generating fragments that include the D-dimer. This makes D-dimer a specific indicator of breakdown of cross-linked fibrin, not of fibrinogen synthesis, platelet aggregation, or plasminogen activation alone. A negative result helps rule out thrombotic events in low-risk patients, while a positive result reflects recent or ongoing fibrinolysis.

D-dimer is produced when plasmin degrades cross-linked fibrin. After a clot forms, fibrin is stabilized by cross-links created by factor XIIIa. When fibrinolysis occurs, plasmin cleaves this cross-linked fibrin, generating fragments that include the D-dimer. This makes D-dimer a specific indicator of breakdown of cross-linked fibrin, not of fibrinogen synthesis, platelet aggregation, or plasminogen activation alone. A negative result helps rule out thrombotic events in low-risk patients, while a positive result reflects recent or ongoing fibrinolysis.

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