PT/INR test assesses which coagulation pathways?

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Multiple Choice

PT/INR test assesses which coagulation pathways?

Explanation:
Prothrombin time/INR evaluates how long it takes for plasma to clot when tissue factor is added, which activates the extrinsic pathway starting with factor VII and then feeds into the common pathway (factors II, V, X, and fibrinogen). So PT/INR primarily reflect the extrinsic pathway plus the downstream common pathway. This is why warfarin therapy, which lowers vitamin K–dependent factors II, VII, IX, and X, prolongs PT/INR. In contrast, the intrinsic pathway is assessed by the PTT (APTT), which targets factors XII, XI, IX, and VIII.

Prothrombin time/INR evaluates how long it takes for plasma to clot when tissue factor is added, which activates the extrinsic pathway starting with factor VII and then feeds into the common pathway (factors II, V, X, and fibrinogen). So PT/INR primarily reflect the extrinsic pathway plus the downstream common pathway. This is why warfarin therapy, which lowers vitamin K–dependent factors II, VII, IX, and X, prolongs PT/INR. In contrast, the intrinsic pathway is assessed by the PTT (APTT), which targets factors XII, XI, IX, and VIII.

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