The ristocetin-induced platelet aggregation assay assesses which interaction?

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Multiple Choice

The ristocetin-induced platelet aggregation assay assesses which interaction?

Explanation:
Ristocetin-induced platelet aggregation measures the interaction between platelets and von Willebrand factor, which is mediated by the platelet GPIb receptor. Ristocetin causes von Willebrand factor to bridge platelets via GPIb, leading to platelet aggregation in vitro. This makes the test useful for detecting problems with von Willebrand factor or with the GPIb receptor—deficiency or dysfunction can diminish the aggregation. Other pathways, like ADP-induced aggregation, thrombin activity, or fibrinogen-mediated bridging via GPIIb/IIIa, operate differently and are not assessed by this assay.

Ristocetin-induced platelet aggregation measures the interaction between platelets and von Willebrand factor, which is mediated by the platelet GPIb receptor. Ristocetin causes von Willebrand factor to bridge platelets via GPIb, leading to platelet aggregation in vitro. This makes the test useful for detecting problems with von Willebrand factor or with the GPIb receptor—deficiency or dysfunction can diminish the aggregation. Other pathways, like ADP-induced aggregation, thrombin activity, or fibrinogen-mediated bridging via GPIIb/IIIa, operate differently and are not assessed by this assay.

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