Which of the following is not synthesized in the liver?

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Multiple Choice

Which of the following is not synthesized in the liver?

Explanation:
Von Willebrand factor is not made by liver cells. It comes from endothelial cells that line blood vessels and, in some cases, from megakaryocytes in the bone marrow. It’s stored in Weibel-Palade bodies in endothelial cells and released when vessels are injured to help platelets adhere and to stabilize circulating Factor VIII. In contrast, plasminogen and protein C are produced by the liver, and Factor VIII is produced mainly by endothelial cells (including hepatic sinusoidal endothelium) rather than by liver cells themselves. So the substance not synthesized in the liver is von Willebrand factor.

Von Willebrand factor is not made by liver cells. It comes from endothelial cells that line blood vessels and, in some cases, from megakaryocytes in the bone marrow. It’s stored in Weibel-Palade bodies in endothelial cells and released when vessels are injured to help platelets adhere and to stabilize circulating Factor VIII. In contrast, plasminogen and protein C are produced by the liver, and Factor VIII is produced mainly by endothelial cells (including hepatic sinusoidal endothelium) rather than by liver cells themselves. So the substance not synthesized in the liver is von Willebrand factor.

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