Which statement is true regarding von Willebrand factor production?

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Multiple Choice

Which statement is true regarding von Willebrand factor production?

Explanation:
VWF is produced by endothelial cells lining blood vessels and by megakaryocytes in the bone marrow, not by the liver. The liver makes many coagulation factors, but von Willebrand factor is not among them. So the statement that it is not synthesized in the liver is true. While megakaryocytes in the bone marrow do contribute to VWF associated with platelets, production is not exclusive to the bone marrow because endothelial cells are a major source as well. The spleen and liver do not synthesize VWF.

VWF is produced by endothelial cells lining blood vessels and by megakaryocytes in the bone marrow, not by the liver. The liver makes many coagulation factors, but von Willebrand factor is not among them. So the statement that it is not synthesized in the liver is true. While megakaryocytes in the bone marrow do contribute to VWF associated with platelets, production is not exclusive to the bone marrow because endothelial cells are a major source as well. The spleen and liver do not synthesize VWF.

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